If the subject line of the email is irrelevant to customers, they will ignore it multiple times. But, if it keeps repeating, they are intercepted and unsubscribed from your emails. So, send relevant emails for the benefit of the customer. Don't send emails that often only focus on sales, offers and discounts.
Раскрыты подробности о договорных матчах в российском футболе18:01
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Жители Санкт-Петербурга устроили «крысогон»17:52
Never the primary choice, but some are frequently recommended as alternatives.